What Is Hdac2

Class I HDACs HDAC1 HDAC2 HDAC3 and HDAC8 are ubiquitously expressed nuclear proteins with close homology to the yeast RPD3.

What is hdac2. A gene on chromosome 6q21 that encodes histone deacetylase 2 which belongs to the histone deacetylase family which form large multiprotein complexes and adeacetylate lysine residues at the N-terminal regions of core histones H2A H2B H3 and H4. Down-regulation of HDAC2 expression mediates proliferation inhibition and cell cycle arrest in HeLa cells. The enzyme known as HDAC2 turns genes off by condensing them so tightly that they cant be expressed.

HDAC2 is the major HDAC for oocyte development by regulating histone acetylation transcription and DNA methylation. Among its related pathways are p53 Signaling and Activated PKN1 stimulates transcription of AR androgen receptor regulated genes KLK2 and KLK3. Histone deacetylase 2 HDAC2 is a class I histone deacetylase family member that plays a critical role in suppressing inflammatory gene expression in the airways lung parenchyma and alveolar macrophages in patients with chronic obstructive pulmonary disease COPD.

HDAC2 forms transcriptional repressor complexes by associating with various proteins including YY1a. This gene product belongs to the histone deacetylase family. Diseases associated with HDAC2 include Pulmonary Disease Chronic Obstructive and Endometrial Stromal Sarcoma.

Its action is opposite to that of histone acetyltransferase. For several years scientists and pharmaceutical companies have been trying to develop drugs that block this enzyme but most of these drugs also block other members of the HDAC family which can lead to toxic side effects. Additionally HDAC2 can catalyze the.

HDAC2 can attenuate lipopolysaccharide-induced inflammation by regulating c-Jun and PAI-1 expression in macrophages. May be involved in the transcriptional repression of circadian target genes such as PER1 mediated by CRY1 through histone deacetylation. This is important because DNA is wrapped around histones and DNA expression is regulated by acetylation and de-acetylation.

Histone acetylationdeacetylation process is important for mediation of transcriptional regulation of many genes. HDAC2 is also critical for. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones H2A H2B H3 and H4.